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either exciting or inhibitory, according to the kind of impulses which different peripheral irritants may send into it. We believe that these centres may, under different external conditions, become either exciting or inhibitory, and that in their present doubtful nature the name of thermotaxic will be the best designation of them.

Résumé.-1. There are four cerebral heatcentres, located (1) in front of and beneath the corpus striatum; (2) the parts on the median side of the nodus cursorius; (3) the parts about Schiff's crying-centre; (4) the anterior inner end of the optic thalamus.

2. These centres are exciting or inhibitory according to the kind of impulses sent into them by the peripheral nerve-endings.

3. The respiratory and circulatory changes induced by the puncture have not any effect upon the course of the temperature generated by the heat-centres just mentioned.

4. The puncture into the thermotaxic centres either partially removes their inhibition on the spinal thermogenic centres, or causes them to become exciting centres acting in conjunction with the spinal heat-centres, and thus generating increased chemical metamorphosis of the tissues and heightened temperature.

Appended are some of the experiments upon which the preceding statements are based.

Second day.

Time.

Cal. temp.

Rec. temp.

Α.Μ.

11.15

84.7°

12.15

85.15°

103.3° 103.0°

18.74 17.96

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Heat dissipation after puncture.
Heat production after puncture...........

Time. P.M.

9.00

Third day.

Time. Α.Μ.

7.42

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Time.
Α.Μ.

9.05

10.05

Cal. temp.

Rec. temp.

83.5°

101.9°

84.4°

101.9°

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11.32

63

76

40

11.41

60

68

102.4°

11.45

61

72

48

102.7°

12.00

60

76

102.8°

P.M.

1.30

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pounds.

Time.

Cal. temp.

Rec. temp.

Α.Μ.

10.35

84.7°

102.3°

11.35

88.2°

101.9°

11.40 Puncture about Schiff's crying-centre.

P.M.

12.15

....

103.5°

1.50

......

103.20

2.00

105.5°

3.00

4.00

86.4°
86.9°

105.3°

105.1°

6.00

105.00

7.40

10.00

104.3°

1

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Second day.

.....

101.7°

101.3°

101.4°

Time.

Cal. temp.

Rec. temp.

P.M.

4.00

85.8°

106.7°

5.00

86.7°

105.8°

Heat dissipation.

37.54

Heat production..

35.38

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Heat dissipation after puncture........

28.36

Heat production before puncture..........

...

19.63

Heat production after puncture

29.99

Time.

Cal. temp.

Rec. temp.

P.M.

8.30

...

104.5°

Second day; weight, 2.44 pounds.

Time.

Cal. temp.

Rec. temp.

P.M.

12.10

85.95°

101.4°

1.10

86.30°

101.7°

1.20

Puncture into right corpus striatum about

the middle.

2.10

102.9°

4.00

5.00

87.2°
87.5°

104.1°

105.1°

Time.

Cal. temp.

Rec. temp.

AM.

Heat dissipation before puncture.......

Heat dissipation after puncture..

Heat production before puncture

14.60

11.52

84.4°

104.6°

12.51

12.52

85.0°

104.3°

15.62 Heat dissipation

25.63

Heat production after puncture

....

15.91

Heat production

24.43 Time.

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P.M.

2.00

Pulse.

54

Pressure.

Rec. temp.

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Puncture into right corpus striatum.

Experiment 24.-Rabbit.

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P.M.

2.44

Cal. temp.

Rec. temp.

103.3°

Puncture in thalamic heat-centre; cortex

not injured.

2.45

......

103.3°

3.00

......

103.5°

4.05

......

105.4°

5.45

......

105.5°

7.45

105.1°

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